Routinely named a top stay in the country, this Gilded Age mansion would be the ideal setting for an elaborate Clue dinner party – and who wouldn't die for a glimpse of these Tiffany stained-glass windows, Italian crystal chandeliers and hand-carved mahogany moldings? An enclosed cupola on the roof offers breathtaking cityscapes, and the service here redefines Southern hospitality.
The 21 distinct rooms are adorned in fine antiques and elegant period furnishings, and there's complimentary sherry, brandy, wine and snacks (read: feast) in the evening. The hotel's romantic restaurant, Circa 1886, features expertly prepared Lowcountry cuisine and a vast wine list, and the intimate spa Urban Nirvana is set in gorgeously converted stables defined by elegant brick and exposed wood beams. Treatments are nothing short of transportive.