One of the more haute and hip options in downtown New Orleans, the downstairs bar at the Catahoula specializes in pisco-based cocktails, in case it wasn't obvious (Pisco, for the uninitiated, is a brandy from Peruvian and Chilean wine regions). You'd think this would make for a one-trick-pony bar, but the cocktails here are diverse and delicious.
There's also a rooftop bar at the Catahoula that specializes in South American wines.