Holiday Inn opened its Kayseri branch in 2017 and it hasn't put a foot wrong. Bang in the central city, the modern, comfortable, super-quiet rooms (even those facing the main road) come with great amenities and good-sized bathrooms with walk-in showers. It's even solved Kayseri's smoky-room problem by creating a separate smoking floor.
There's a cafe on the ground floor and a restaurant on the top floor.