This magnificent church is testament to the close links that once existed between the Neapolitan Aragonese and the Florentine Medici dynasty. One particular highlight is Guido Mazzoni's spectacular Pietà. Dating from 1492, the terracotta ensemble is made up of eight life-size terracotta figures surrounding the lifeless body of Christ. Originally the figures were painted, but even without colour they still make quite an impression. Also impressive is baroque painter Francesco Solimena's arresting depiction of St Christopher.
The sacristy is a work of art in itself. The walls are graced with gloriously inlaid wood panels by Giovanni da Verona, while the ceiling bursts with 16th-century frescoes by Giorgio Vasari depicting the Allegories and Symbols of Faith.
Across Via Monteoliveto from the church is the 16th-century Palazzo Orsini in Gravina, the seat of Naples University's architecture faculty.