Named after the 15th-century Spanish scholar Rabbi Yitzhak Abuhav, this synagogue was founded in the 16th century but moved to its present location after the 1759 earthquake. The ornately carved courtyard, restored in the late 20th century, is often used for weddings.
Inside, the four central pillars represent the four elements (earth, air, water and fire) that, according to Kabbalists (and ancient Greeks such as Aristotle), make up all of creation. The oval dome has 10 windows, one for each of the Ten Commandments; representations of the 12 Tribes of Israel; illustrations of musical instruments used in the Temple; pomegranates (said to have the same number of seeds as there are Jewish commandments, 613); and the Dome of the Rock, a reminder of the Temple in Jerusalem.