Cincinnati chili is a local specialty. A 'five-way' is a version comprised of meat sauce (spiced with chocolate and cinnamon) ladled over spaghetti and beans, then garnished with cheese and onions. Although you can get it three-way (minus onions and beans) or four-way (minus onions or beans), you should go the whole way. Skyline has a cult-like following devoted to its recipe.
The chili maker has outlets throughout town; this one is downtown near Fountain Sq.