An exquisite 1879 building awash with wooden floors, carved ceilings and a rooftop pool, this splendid address occupies the former headquarters of the Cottonmakers' Guild, which you'll notice from the lobby's huge sprays of cotton bolls to the room names (Damask, Egyptian, Taffeta). All-white rooms are elegantly styled, with wide beds, rain showers and Ortigia toiletries; back rooms have balconies.
There's even a space off the library where you can have a shirt custom made using original guild patterns.